Tricyclic antidepressants

Tricyclic antidepressants

In 1958, a clinical study of imipramine, a drug which was originally synthesized to be an antipsychotic, reveals its antidepressant properties. It therapeutically functions by affecting the brain activity of the neurotransmitters (stimulus transmitting agents). So many subsequent effective drugs in this class are developed that the entire group becomes known as `tricyclic' antidepressants. Tricyclic antidepressants become the standard of therapy for this disease.


Did you know?

One of the greatest artists suffering from severe depression was Vincent Van Gogh, whose self portraits reflect his gloomy mood and hopelessness. In addition, Dostoyevsky, Hemingway, Louis II, and Princess Elisabeth of Hungary also suffered from depression.