Insulin

Frederick BantingFrederick Banting

Insulin

> Insulin, first isolated by the Romanian Nicolae Paulescu in 1921, is a protein hormone produced by special cells of the pancreas, which controls the amount of blood sugar (glucose) in the blood. Lack of insulin leads to the development of a fatal disease, diabetes type I. Two young Canadian doctors, Frederick Banting and Charles H. Best were the first to use this new injectable extract from bovine pancreas for medical purposes.Their first patient was a dying 14-year-old boy, who was released from the hospital in few weeks.

Diabetes is diagnosed by demonstrating any one of the following: plasma glucose level ≥ 7.0 mmol/L (200 mg/dL) on an empty stomach; and plasma glucose level ≥ 11.1 mmol/L (200 mg/dL) two hours after a 75 g oral glucose load.Diabetes is diagnosed by demonstrating any one of the following: plasma glucose level ≥ 7.0 mmol/L (200 mg/dL) on an empty stomach; and plasma glucose level ≥ 11.1 mmol/L (200 mg/dL) two hours after a 75 g oral glucose load.

 

Charles H. BestCharles H. Best

Insulin was produced from bovine pancreas by Eli Lilly and Company in 1922. The first insulin engineered from human sources using recombinant DNA technology was produced in 1982.

Did you know?

Diabetes mellitus appears to have been a death sentence until 1921. Today, at least 250 million people worldwide suffer from diabetes, 95 % of whom live in industrialized countries; thus, diabetes is considered a disease of civilization.