Evolution of ulcer therapy

James BlackJames Black

Evolution of ulcer therapy

In 1972, James Black and his colleagues at Smith, Kline & French shed light on the basis of surplus acid secretion in the stomach. This type of pharmaceutical research is now called rational drug design. By 1975, their cimetidine (Tagamet) inhibited gastric acid secretion with minimal side-effects, and . Tagamet was first launched on the market in Great Britain in 1976. It revolutionized the treatment for gastric ulcers and soon became the most frequently prescribed drug. It effectively inhibits the production of acid in the stomach without serious side effects. Its widespread use for gastric ulcers has dramatically decreased the need for surgery.

Helicobacter pylori bacterium under a microscope

The first signs of gastric ulcer: regular burning pain in the epigastric area.The first signs of gastric ulcer: regular burning pain in the epigastric area.

Did you know?

Helicobacter pylori was first discovered in the stomachs of patients with gastritis and stomach ulcers in 1982 by Nobel laureate Dr. Barry Marshall and Dr. Robin Warren. More than 50% of the world's population harbour H. pylori in their upper gastrointestinal tract, and approx. 15% of them suffer from gastric ulcer. Today, the presence of H. pylori bacteria in the body can be indicated by a simple breath test.