In 1972, James Black and his colleagues at Smith, Kline & French shed light on the basis of surplus acid secretion in the stomach. This type of pharmaceutical research is now called rational drug design. By 1975, their cimetidine (Tagamet) inhibited gastric acid secretion with minimal side-effects, and . Tagamet was first launched on the market in Great Britain in 1976. It revolutionized the treatment for gastric ulcers and soon became the most frequently prescribed drug. It effectively inhibits the production of acid in the stomach without serious side effects. Its widespread use for gastric ulcers has dramatically decreased the need for surgery.
Helicobacter pylori bacterium under a microscope