Chlorpromazine (Thorazine, Hibernal) was first used to treat schizophrenia in 1954 after its original creation as an antihistamine anti-allergic. This new substance dramatically proved itself and quickly heralded the modern era of antipsychotic therapy, and became a reference of the central nervous system drugs.
Controlling mental illness through medication soon supplanted earlier treatment methods and decreased the rate of institutionalization worldwide from 1955-1970. Chlorpromazine was the first drug that served as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents.
One Flew Over the Cucoo's Nest (1975), demonstrating disastrous mental disease