Benzodiazepines

Leo SternbachLeo Sternbach

Benzodiazepines

In 1959, chlordiazepoxide (Librium) debuts and launches a potent new class of antianxiety agents, the benzodiazepines. Benzodiazepines and subsequent derivatives rapidly replaced barbiturates and meprobamate, an earlier moderately successful anxiolytic agent discovered in 1950.

Classic symptoms of anxiety disorder:  anxiety attacks, tightness or pain in the chest, and insomniaClassic symptoms of anxiety disorder: anxiety attacks, tightness or pain in the chest, and insomnia

Chlordiazepoxide molecule


Today, benzodiazepines are considered among the most successful drugs treating the problems of the central nervous system. The highly tolerable and safe benzodiazepines also prove successful as hypnotic agents, muscle relaxants, and for treatment of epilepsy.

Relaxants and antianxiety agents containing benzodiazepinesRelaxants and antianxiety agents containing benzodiazepines

Alprazolam (Xanax, Frontin), Diazepam (Seduxen), Nitrazepam (Eunoctin), Clonazepam (Rivotril), Flunitrazepam (Rohypnol), Flumazenil (also used as an antidote in the treatment of benzodiazepine overdoses) (Anexate), Midazolam (Dormicum)

Did you know?

Anxiety disorders include a wide variety of phobia, which is an irrational, intense and persistent fear of certain situations, activities, things, animals, or people. Its most common forms are agoraphobia, claustrophobia, and acrophobia.